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sign  (sīn)n.1. Something that suggests the presence or existence of a fact, condition, or quality: A high temperature is a sign of fever.2. a. An act or gesture used to convey an idea, a desire, information, or a command: gave the go-ahead sign. See Synonyms at gesture.b. Sign language.3. a. A displayed structure bearing lettering or symbols, used to identify or advertise a place of business: a motel with a flashing neon sign outside.b. A posted notice bearing a designation, direction, or command: an EXIT sign above a door; a traffic sign.4. A conventional figure or device that stands for a word, phrase, or operation; a symbol, as in mathematics or in musical notation.5. pl. sign An indicator, such as a dropping or footprint, of the trail of an animal: looking for deer sign.6. A trace or vestige: no sign of life.7. A portentous incident or event; a presage: took the eclipse as a sign from God.8. Medicine An objective finding, usually detected on physical examination, from a laboratory test, or on an x-ray, that indicates the presence of abnormality or disease.9. One of the 12 divisions of the zodiac, each named for a constellation and represented by a symbol.v. signed, sign·ing, signs v.tr.1. To affix one's signature to: signed the letter.2. To write (one's signature): signed he