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probe  (prōb)n.1. a. A slender, flexible surgical instrument used to explore a wound or body cavity.b. An electrode or other device that can be placed inside something to take and convey measurements.c. A substance, such as DNA, that is radioactively labeled or otherwise marked and used to detect or identify another substance in a sample.d. A space probe.2. a. An exploratory action or expedition, especially one designed to investigate and obtain information on a remote or unknown region: the scouts' probe of enemy territory.b. The act of exploring or searching with a device or instrument: the surgeon's probe of the clogged artery.c. An investigation into unfamiliar matters or questionable activities; a penetrating inquiry: a congressional probe into price fixing; a reporter's probe into a public figure's past. See Synonyms at inquiry.v. probed, prob·ing, probes v.tr.1. a. To penetrate or explore physically, especially with a probe, in order to find or discover something: Chimpanzees use a variety of tools to probe termite mounds (Virginia Morell).b. To investigate by means of a chemical probe.2. a. To make an inquiry about (something); investigate or examine: probed the impact of technology on social behavior.b. To subject (a person) to questioning; interrogate.v.intr.1. To make a p