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fissionfission of a uranium nucleusfis·sion  (fĭsh′ən, fĭzh′-)n.1. The act or process of splitting into parts.2. A nuclear reaction in which an atomic nucleus, especially a heavy nucleus, such as an isotope of uranium, splits into fragments, usually two fragments of comparable but unequal mass, and releases a few neutrons and about 100 million electron volts of energy. Nuclear fission may occur spontaneously or may be induced by the absorption of a neutron, which can initiate a nuclear chain reaction.3. Biology An asexual reproductive process in which a unicellular organism divides into two or more independently maturing daughter cells.v. fis·sioned, fis·sion·ing, fis·sions v.tr. To cause (an atom) to undergo fission.v.intr. To undergo fission.[Latin fissiō, fissiōn-, a cleaving, from fissus, split; see fissi-.]