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mole 1  (mōl)n. A skin lesion, commonly a nevus, that is typically raised and discolored.[Middle English, from Old English māl.]mole 2  (mōl)n.1. Any of various small insectivorous mammals of the family Talpidae of North America and Eurasia, usually living underground and having a thickset body with light brown to dark gray silky fur, strong forefeet for burrowing, and often rudimentary eyes.2. A machine that bores through hard surfaces, used especially for tunneling through rock.3. A spy who operates from within an organization, especially a double agent operating against his or her own government from within its intelligence establishment.[Middle English molle; possibly akin to mold.]mole 3  (mōl)n.1. A massive, usually stone wall constructed in the sea, used as a breakwater and built to enclose or protect an anchorage or a harbor.2. The anchorage or harbor enclosed by a mole.[French môle, from Italian molo, from Late Greek mōlos, from Latin mōlēs, mass, mole.]mole 4  (mōl)n. A fleshy abnormal mass formed in the uterus by the degeneration or abortive development of an ovum.[French môle, from Latin mola, millstone, mole; see melə- in Indo-European roots.]mole 5  (mōl)n. Abbr. mol Chemistry In the International System, the base unit used in representing an amount of a substance, equal to the amount o